Post by mirrororchid on Jul 25, 2023 8:12:23 GMT -5
A pretty solid article on Nitroglycerine Gel with more specifics than resources I may have used in the past, including contraindications and caveats worth knowing:
While the article starts to suggest the ointment can work in combination with sildenafil (Viagra):
"[Topical nitroglycerin] acts as a nitrogen donor to increase local levels of nitric oxide, which works through molecular signaling (cGMP pathway) to cause this response,” he says...
On the other hand, Brito says PDE5 inhibitors (like tadalafil and sildenafil) work at a later step in the chain by inhibiting the breakdown of cGMP....studies used concentrations of 0.2% to 0.8% for people with more severe ED, who likely need higher concentrations....nitroglycerin paste or gel applied to the chest for chest pain, which is a 2% paste. It’s important not to mix up the two when applying to the penis. If you apply a pea-sized amount, this is about 0.15 to 0.25 grams"
It later says:
"...taking nitroglycerin-based medications with certain PDE5 inhibitors like Viagra is contraindicated. Using them together can result in a sudden and serious decrease in blood pressure and potentially death."
Too much of a good thing! So, one at a time, clearly, preferably with physician consultation.
If nitroglycerine gel had a commercial, this might be the legalease they say at the end really really fast:
There are many medications that cause negative side effects if you use them with nitroglycerin gel too. While there are quite a few, some of the main ones are sildenafil (Viagra), aspirin, or ergotamine, which treats migraine.
Avoid using nitroglycerin gel if you have health conditions like anemia or hypotension. Using nitroglycerin can make these conditions worse...Nitroglycerin gel can cause unwanted side effects. Examples of these effects include:
blurry vision
dry mouth
feeling faint
headache
low blood pressure
nausea
rapid heart rate
You could also experience an allergic reaction where you apply the nitroglycerin. An allergic reaction could include redness, swelling, or itching.
If you experience these symptoms, stop using nitroglycerin gel immediately. Remove any excess and avoid touching the nitroglycerin with your hands to ensure your symptoms don’t get worse.
Seek immediate medical attention if your symptoms don’t improve after a few minutes or you’re having trouble breathing.
Hmph. Such a buzzkill.
Then this chaser:
"However, it also doesn’t last very long in the body — usually only a few minutes."
The article mentions avoiding getting the ointment on your partner (accidental exposure can produce "low blood pressure. This can lead to headaches and nasal congestion."). This can be avoided by applying it on the taint, or using a condom if using the head as the researcher recommends . Perhaps the choice can be dictated on whether the taint is adequate to the task.
"Topical nitroglycerin can work anywhere that you apply it. That’s why you should wear gloves or another protective covering (like a finger covered in plastic wrap) before putting it on your penis. Squeeze a pea-sized dot on your finger and apply to the head of your penis.
Typically, your body will rapidly absorb the nitroglycerin. If enough time passes after application, the gel shouldn’t affect your partner."
Well, a little good news, but if the gel only lasts a few minutes, does that do any good?
The contradictions make me want to hear some reports form the field if anyone deices to try it.
While the article starts to suggest the ointment can work in combination with sildenafil (Viagra):
"[Topical nitroglycerin] acts as a nitrogen donor to increase local levels of nitric oxide, which works through molecular signaling (cGMP pathway) to cause this response,” he says...
On the other hand, Brito says PDE5 inhibitors (like tadalafil and sildenafil) work at a later step in the chain by inhibiting the breakdown of cGMP....studies used concentrations of 0.2% to 0.8% for people with more severe ED, who likely need higher concentrations....nitroglycerin paste or gel applied to the chest for chest pain, which is a 2% paste. It’s important not to mix up the two when applying to the penis. If you apply a pea-sized amount, this is about 0.15 to 0.25 grams"
It later says:
"...taking nitroglycerin-based medications with certain PDE5 inhibitors like Viagra is contraindicated. Using them together can result in a sudden and serious decrease in blood pressure and potentially death."
Too much of a good thing! So, one at a time, clearly, preferably with physician consultation.
If nitroglycerine gel had a commercial, this might be the legalease they say at the end really really fast:
There are many medications that cause negative side effects if you use them with nitroglycerin gel too. While there are quite a few, some of the main ones are sildenafil (Viagra), aspirin, or ergotamine, which treats migraine.
Avoid using nitroglycerin gel if you have health conditions like anemia or hypotension. Using nitroglycerin can make these conditions worse...Nitroglycerin gel can cause unwanted side effects. Examples of these effects include:
blurry vision
dry mouth
feeling faint
headache
low blood pressure
nausea
rapid heart rate
You could also experience an allergic reaction where you apply the nitroglycerin. An allergic reaction could include redness, swelling, or itching.
If you experience these symptoms, stop using nitroglycerin gel immediately. Remove any excess and avoid touching the nitroglycerin with your hands to ensure your symptoms don’t get worse.
Seek immediate medical attention if your symptoms don’t improve after a few minutes or you’re having trouble breathing.
Hmph. Such a buzzkill.
Then this chaser:
"However, it also doesn’t last very long in the body — usually only a few minutes."
The article mentions avoiding getting the ointment on your partner (accidental exposure can produce "low blood pressure. This can lead to headaches and nasal congestion."). This can be avoided by applying it on the taint, or using a condom if using the head as the researcher recommends . Perhaps the choice can be dictated on whether the taint is adequate to the task.
"Topical nitroglycerin can work anywhere that you apply it. That’s why you should wear gloves or another protective covering (like a finger covered in plastic wrap) before putting it on your penis. Squeeze a pea-sized dot on your finger and apply to the head of your penis.
Typically, your body will rapidly absorb the nitroglycerin. If enough time passes after application, the gel shouldn’t affect your partner."
Well, a little good news, but if the gel only lasts a few minutes, does that do any good?
The contradictions make me want to hear some reports form the field if anyone deices to try it.
