Efficacy of antidepressants against placebo

Thought I had posted this already.
This is a list of nine antidepressants from nine pharmaceutical classes, in order of efficacy and side effect severity, based on the efficacy chart at the start of this thread.







I suggest trying them in order. If it fails to help, or stops working eventually, move on to the next.



If one works, consider using another antidepressant in the same class of drugs with a more mild side effect profile if the most powerful drug of its kind is a winner, but has drawbacks for you.



If all nine fail, you start getting into less well researched areas. Trans cranial stimulation, Cannabidiol, Ketamine, Psilocybin, among others.

Health professionals may even prefer trying one of these four before the drug classes with more difficult side effect profiles such as TriCyclics or MAO inhibitors (oral, rather than transdermal)
Health professionals may also want to switch up the order of these nine, which isn't so bad, but what I'd want people to do is question a doctor that wants to put you on three drugs of the same class (they just love SSRIs) before trying a different drug class. This is standard practice, and it's bad.

Patients think they have tried four antidepressants when they've only really had two. Such a practice minimizes side effects and complications, but may produce abandonment of treatment leaving lots of plausible, effective therapies on the table.